The Reds are 13 and 14 points ahead of Leicester and Manchester City respectively with a game in hand and, should they navigate their way through a tricky looking run of games in January, they will have at least one hand firmly on their maiden Premier League title.
Tottenham, meanwhile, have hit their first slump under manager José Mourinho, with talismanic striker Harry Kane out until April with a hamstring injury.
Following just four points from their last four league games, Spurs have lost ground on Chelsea in the race for the fourth and final Champions League qualification spot, currently languishing six points behind their London rivals.
However, the bookmakers actually have this match as the most likely first league loss of the season for Liverpool, with a Tottenham win priced at 18/5.
An away win for the runaway leaders is 4/6, with the draw 3/1.
Liverpool have won 2-1 an astonishing seven times this season in the league alone and, despite the Reds’ recent run of clean sheets, Spurs still have enough in attack to threaten their back-line even without Kane.
11/5 is the price for a Liverpool win with both teams to score, with 8/1 on the correct score of 2-1 looking very appealing.
Given the likelihood of at least two Liverpool goals, 11/8 for Sadio Mané to score anytime is also a good price. The Senegal international should thrive against full-back Serge Aurier, who despite recent improvement remains defensively absent-minded at times, as was evident at Anfield earlier in the season when he clumsily fouled Mané to give away a penalty.
Roberto Firmino has scored all six of his Premier League goals away from Anfield this campaign and at 2/1 to score anytime, the Brazilian also looks good value.
Mohamed Salah is a little skinnier at 7/5; with just one league goal on the road this campaign, his two team-mates look better value for this match, but obviously the Egyptian is more than capable of adding to that tally.
For Spurs, 9/2 on Dele Alli to score anytime looks more than reasonable with him likely to play very advanced in Kane’s absence.
Lucas Moura is 11/4, with Son Heung-Min 21/10.