Spurs and the Magpies each sit on three points having won once and lost once this season.
Jose Mourinho’s men kicked their campaign off with a 1-0 home loss to Everton, but recovered with a stunning 5-2 win at Southampton.
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The pair were also in action throughout the week, with Mourinho’s side in Europa League action and Steve Bruce’s men in League Cup action.
Spurs won 3-1 in their third qualifying round tie against Shkendija, with Newcastle thumping lower league outfit Morecambe 7-0 in the third round of the cup.
But all eyes will now be on Sunday’s meeting at Tottenham Hotspur Stadium.
Tottenham v Newcastle Utd : Is there a Bet Builder Tip on the game?
The hosts are currently 1/2 to come out on top, with the visitors available at 13/2.
A draw has been given odds of 15/4.
Last season’s league encounters between the sides certainly produced two surprising results, with the Magpies winning 1-0 away from home in August.
Spurs then won their away game almost a year later, running out 3-1 victors at St James’ Park.
It’s currently 19/1 for another 1-0 win for Bruce’s outfit, with Mourinho’s men available at 12/1 to clinch another 3-1 victory.
Harry Kane scored twice in the most recent meeting between the sides, and he is currently 5/6 to find the net once again on Sunday.
His team-mate Son Heung-min was also on the scoresheet that day, and he has continued his goalscoring exploits this season.
The South Korean netted four in the win at Southampton, and is currently 6/4 to score another.
But recent Newcastle arrival Callum Wilson will be keen to add to his tally having netted in the opening day win at West Ham.
The striker can be backed at 16/5 to score anytime. Fellow forward Andy Carroll is available at 22/5.
The fixture represents the start of a difficult period for Bruce and his squad, who face Manchester United, Wolves and Everton in the coming weeks.
Spurs also have an upcoming meeting with United, but that comes after their Europa League play-off tie with Maccabi Haifa.
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