Pep Guardiola’s side got their season off to a winning start at Wolverhampton Wanderers on Monday night, with Kevin de Bruyne, Phil Foden and Gabriel Jesus scoring in an impressive 3-1 win.
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Leicester, meanwhile, have quickly put the disappointment of missing out on Champions League qualification behind them and head into the weekend top of the table with a 100% record. Some of their attacking football in the 4-2 win over Burnley would have been very encouraging for Brendan Rodgers.
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However, the Foxes head to the Etihad as huge 17/2 underdogs to win the match. Man City are 2/7, with the draw 5/1.
Guardiola made 10 changes in midweek, with only holding midfielder Rodri Hernandez retaining his place in the 2-1 win against Bournemouth.
Rodgers changed his entire starting XI in the EFL Cup defeat to Arsenal, meaning his key players should be fresh for the huge challenge ahead of them.
However, one huge loss for them will be Wilfred Ndidi, who has been ruled out for up to three months with an abductor injury. The midfielder has been filling in for the suspended Jonny Evans at centre-half in recent weeks.
While the Northern Ireland defender is now available again for selection, Evans has also been suffering with an injury sustained on international duty earlier this month, meaning club captain Wes Morgan may be forced to start.
Man City may have won the last four meetings between the two sides at the Etihad, but Jamie Vardy has an impressive six goals in 11 games against the Citizens and is 9/4 to score anytime (Unibet).
Winger Harvey Barnes is a player I’ve had my eye on since his loan spell at West Brom, and the 22-year-old has looked in superb form in the opening two games. He looks a huge price at 6/1 to score (Betfair), as he did against Burnley, and also to record two or more shots on target at 9/2 (Sky Bet). The latter has landed in both of Leicester’s league games so far.
Jesus and Raheem Sterling are both evens to get on the score-sheet for the home side (Sky Bet), with Riyad Mahrez 8/5 to curse his former club as he did in this fixture last season (Betfair).
De Bruyne, who is now his side’s regular penalty-taker, and Foden are 9/5 and 9/4 respectively to make it two (or more) goals in two games (Sky Bet).
In terms of a bet365 Bet Builder, I’m struggling to see beyond Man City scoring at least two here on their way to winning given Leicester’s defensive vulnerabilities. Man City also always rack up the corners, averaging 8.25 at home last season, so I’m happy to back them to have five or more.
Michael Oliver referees and he’s generally pretty lenient these days, but he has shown at least one card in 16 of his last 17 Premier League matches, so if we throw that in, too, we get odds of 4/5 on Man City to win & score 2+ goals, Man City to have 5+ corners, over 0 cards for both teams combined.